Apellis Pharmaceuticals Inc. has identified C3 convertase inhibitors reported to be useful for the treatment of cancer, obesity, infections, neurological disorders, autoimmune and inflammatory ...

(The arched arrow on the left represents the amplification loop [i.e., C3 convertase activates more C3].) The cleavage product C5b is at the start of the nonenzymatic assembly of the cytolytic ...

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense ...