Lipid nanoparticle platform delivers mRNA to the brain
Designing BBB organoids posed a technical challenge: growing the two components—the brain ... blood vessels in the BBB. In contrast, blood vessel organoids did not express these molecules before ...
The delivery challenge is posed by the blood–brain barrier (BBB), which prevents around ... Published in vitro and in vivo studies by NEUWAY have validated the transport of EnPCs across the ...
The blood–brain barrier acts as a highly selective shield that protects the brain from harmful substances in the bloodstream. However, this same protective feature makes it difficult for most ...
The findings revealed a novel mechanism through which microplastics indirectly disrupt vascular and neurological functions without crossing the blood-brain barrier ... in vivo, are poorly ...
Researchers at the National University of Singapore have reported crossing the blood–brain barrier with help from a modified Lactobacillus plantarum. By delivering an appetite-regulating hormone ...
They were watching brain scans of a woman named Bonny Hall, who lay inside an MRI machine just a few feet away. Earlier that day, Hall, who had been battling a brain tumor for eight years, had ...
glial cells and the blood-brain barrier following ischemic insult. We also describe the evidence of TRPM2 involvement in these processes, as shown from numerous in vitro and in vivo studies that ...
News Medical on MSN9d
New method provides accurate measurement of drug permeability across the blood-brain barrierFor decades, scientists across the globe have investigated methods to accurately measure drug permeability across the blood-brain barrier, a compact layer of cells that protect the brain from ...
Scientists have developed a lipid nanoparticle system capable of delivering messenger RNA (mRNA) to the brain via intravenous injection, a challenge that has long been limited by the protective nature ...
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