Acute myelogenous leukemia, or AML, remains one of the most aggressive blood cancers. Each year, around 44,000 people in the ...

In the study, "Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation," published in Blood Cancer Discovery ...

This process, known as differentiation, must be precisely regulated to ensure a balanced production of mature blood cells across all cell types. An international team of scientists from ...

This process, known as differentiation, must be precisely regulated to ensure a balanced production of mature blood cells across all cell types. An international team of scientists from ...

They mapped over 1.2 million cells from more than 300 leukemia samples to this reference atlas to determine patterns of aberrant differentiation. Among the different cell differentiation stages that ...

In blood stem cell differentiation, single-cell transcriptomics and imaging-based studies have demonstrated that key TFs are expressed in smooth, overlapping gradients throughout the stem and ...

The research team systematically profiled metabolic changes through each red blood cell maturation stage. “We found that glutamine metabolism is completely reversed during later differentiation, ...

Unlike targeting many other HbF repressors, upregulation of PGC-1 alpha does not affect red blood cell differentiation, suggesting that modulating PGC-1 alpha activity would be a novel and safer ...

While each cell contains the complete genetic ... This impairs the formation of blood cells by disrupting the differentiation of hematopoietic stem cells, inducing excessive production of myeloid ...

The physical forces exerted by a heart beat and the blood flow it produces trigger the formation of new blood cells, according to two studies published today (May 13) in Nature and Cell. Zebrafish ...

An Autolus Therapeutics cell therapy has won FDA approval for treating an aggressive blood cancer ... Phipps said Aucatzyl’s differentiation on safety and REMS reporting warrants a premium ...

Sickle Cell Disease is a chronic, inherited blood disorder that affects millions of people worldwide. It is best known for causing anaemia, pain episodes, and organ complications, but a lesser ...