Mechanism behind autophagy trigger unveiled A research team has uncovered a novel mechanism essential for initiating autophagy Date: September 24, 2024 Source: Osaka University Summary: A research ...

The researchers used fluorescently tagged LC3 to track the autophagy process, and demonstrated that 6-OHDA treatment increased autophagosome formation and enhanced autophagosome-lysosome fusion ...

They also discovered that the PI3K complex, an autophagy-related protein, is essential for this formation process. The activity of the PI3K complex is controlled by the ULK1 complex.

Researchers at the University of Tsukuba have discovered a unique biphasic cellular response triggered by tetrandrine, a ...

Researchers have identified how autophagy and chaperone-mediated autophagy (CMA) drive the unconventional secretion of PARK7, a protein linked to Parkinson's disease. Their findings suggest new ...

Understanding the autophagy mechanism At its core, autophagy is a survival mechanism that allows cells to adapt to changing conditions and stress. When activated, the process identifies damaged ...

These are produced early in the autophagy mechanism, which degrades and reuses foreign substances and proteins in the cell. The autophagy mechanism proceeds when cancer cells, which are rapidly ...

More information: Xun Zhou et al, Chaperone-mediated autophagy regulates the metastatic state of mesenchymal tumors, EMBO Molecular Medicine (2025). DOI: 10.1038/s44321-025-00210-w ...

Polyploidy-associated autophagy promotes larval tracheal histolysis at Drosophila metamorphosis. Autophagy, 2023; 1 DOI: 10.1080/15548627.2023.2231828 ...

A research team from Osaka University has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in ...