stabilizer TH-301 in models of pancreatic ductal adenocarcinoma (PDAC). It was seen that treatment with TH-301 led to significant dose-, time- and cell type-dependent decreases in viability.

Cells break down and recycle their components in a process called autophagy. Researchers now suggest that autophagy may play a role in thwarting cancer. They used healthy human cells and turned off ...

“Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine ... that IRF1 was downregulated in antiestrogen-resistant breast cancer cell lines, ...

Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a self ...

Our cells constantly receive DNA damage from factors such as ultraviolet rays, irradiations, toxins and chemicals. For women, ...

Headed by Drs. Antonio Zorzano and Saska Ivanova, a study published in the journal Autophagy unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing ...

Arginine deprivation also gives rise to a host of conditions within cancer cells, including increased autophagy ... who have failed at least two lines of prior systemic treatments.

Autophagy defects have been linked to aging, as well as, with the emergence of age-related disorders, such as diabetes, ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...