Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway ...

There are several programmed cell death pathways that lead to cellular self-destruction, either for developmental processes, tissue maintenance, or stress responses. These include apoptosis, ...

Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis. Despite ...

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent ... release of caspase activators from mitochondria during apoptosis. Here we ...

Cancer arises when your cells grow uncontrollably and refuse to die when they should. Normally, your body is equipped with ...

Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including ...

Mammalian hosts coordinate various cell death pathways as part of the immune defense system against pathogens including Mycobacterium tuberculosis ...

Bantam Pharmaceutical, a drug discovery and development company targeting selective modulation of mitochondrial dynamics in ...

The following is a summary of “Role of NAT10-mediated ac4C acetylation of ENO1 mRNA in glycolysis and apoptosis in non-small ...

Understanding the molecular mechanisms driving osteocyte death is crucial to developing ... particularly in ferroptosis-related pathways. A key discovery was the activation of the HIF1α-HMOX1 ...