Nature15y
Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells
Imatinib-induced apoptosis was abrogated in LynΔN-overexpressing ... LynΔN also inhibits imatinib-mediated caspase-3 activation in the small proportion of nilotinib-resistant K562 cells ...
Nature4d
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Apoptosis is dependent on caspase activation ... Figure 2: FasL-mediated, caspase-independent cell death in T cells requires FADD. Figure 3: RIP binds to Fas and signals necrotic T cell death.
The Scientist8mon
Multiplexing Caspase-Based Apoptosis Assays with Automated Microscopy
Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark of apoptosis initiation—with fluorescent dyes. Researchers often perform multiplex caspase assays ...
Hosted on MSN9mon
Differentiating cerebral cortical neurons to decipher molecular mechanisms of neurodegeneration
The research team first established several independent iPSC lines ... was observed to significantly reduce caspase-3/7 activation, a hallmark of apoptosis, by nearly 50%, thus suggesting that ...