An erythromycin-producing E. coli recombinant strain with an antibiotic-overproducing mutation in the mycarose biosynthesis pathway produced second-generation mutants capable of directed ...

Aminoglycoside antibiotics, a vital class in the treatment of Gram-negative bacterial infections, are produced via a complex biosynthetic machinery that orchestrates the assembly of diverse sugar ...

Investigations into kanamycin biosynthesis and identification of new pathway intermediates surprisingly point to the substrate specificity of two glycosyltransferases as controlling flux into ...

Scientists at the University of Utah and the University of Georgia have uncovered a pharmacological target that could enable development of novel drugs against antibiotic-resistant pathogens, ...

Duke University. "Synthetic antibiotic could be effective against drug-resistant superbugs." ScienceDaily. ScienceDaily, 9 August 2023. <www.sciencedaily.com / releases / 2023 / 08 / 230809164729 ...

Researchers have discovered a new cell division pathway in MRSA that enables high-level resistance to β-lactam antibiotics, marking a critical insight into the persistence of these 'superbugs'.

Bacteria have antibiotic-defying tricks besides genetically determined resistance. They commonly resort to general defense mechanisms such as persistence, the dialing down of metabolism, growth ...

Herbicide resistance represents a huge problem for the agricultural sector. Exploiting molecular similarities between bacteria and plants, researchers have repurposed a "failed" antibiotic as an ...

Institut Pasteur. "Genetics: Biosynthesis pathway of a new DNA nucleobase elucidated." ScienceDaily. ScienceDaily, 10 July 2021. <www.sciencedaily.com / releases / 2021 / 07 / 210709130112.htm>.

Now scientists have identified the biosynthetic pathway for one of those key precursors, baccatin III—which means that easier methods of paclitaxel manufacturing could be coming soon (Nature ...

2-aminoadenine biosynthesis pathway elucidated Since it was discovered in 1977, cyanophage S-2L has been the only known exception, and the biosynthesis pathway of 2-aminoadenine has remained unknown.