Scientists have discovered a new chemical process – also known as a biosynthetic pathway – in bacteria which could lead to a new generation of antibiotics being produced and manufactured. Researchers ...

particularly in the context of combating antibiotic resistance and developing new herbicides. One significant area of research is the role of the cysteine biosynthesis pathway in bacterial pathogens.

Recent studies have highlighted the coordinated action of various enzymes in the lysine biosynthetic pathway, emphasizing the potential of this pathway as a target for new antibiotics. A ...

Using synthetic biology we are able to rewrite the DNA sequences of the antibiotic biosynthesis pathways and introduce different enzymes for other organisms and then express the result in a given host ...

This applies specifically to Gram-negative bacteria, which are protected from antibiotic ... with metabolic pathways that ...

“The overwhelming majority of antibiotics in clinical use are natural products ... as well as new ways to engineer the biosynthetic pathways for clinically-used compounds to produce new derivatives.” ...

The compound, called LPC-233, is a small molecule that has proven effective at wrecking the outer membrane lipid biosynthesis ... his work on this pathway at Merck & Co. had failed to produce a ...

In this work, they focused on peptide condensation of two key modules involved in producing tyrocidine B, a natural antibiotic ... which helps ensure the pathway runs smoothly.