Hyperchloremic, Normal Anion-Gap, Metabolic Acidosis Due to Topiramate Kathryn D. Mathews, PharmD; Jennifer E. Stark, PharmD, BCPS Disclosures Am J Health Syst Pharm. 2008;65 (15):1430-1434.

A low anion gap result on a blood test is often a technical error, though it can stem from a health issue. Here, learn what low and high anion gap results mean.

The anion gap was 41. The plasma osmolarity was 314 mOsm/L. The plasma lactate was 25.9 mmol/L. The plasma pH was less than 6.8. His urine drug screen was negative for illicit drugs or ethanol.

Technical Terms Anion gap: The calculated difference between measured cations (e.g. sodium) and anions (e.g. chloride and bicarbonate) in the blood, used to assess acid–base status.

The American Diabetes Association (ADA) defines DKA as a combination of hyperglycemia with a blood glucose ≥250 mg/dL, a metabolic acidosis with bicarbonate ≤18 mEq/L, an anion gap >10, and ...

Hyperchloremic, Normal Anion-Gap, Metabolic Acidosis Due to Topiramate Kathryn D. Mathews, PharmD; Jennifer E. Stark, PharmD, BCPS Disclosures Am J Health Syst Pharm. 2008;65 (15):1430-1434.