Researchers developed trehalose-functionalized peptide amphiphiles (TPAs) that self-assemble into supramolecular ...

Amyloid fibrils of Aβ form a parallel, in-register cross β-sheet structure. The accumulation of Aβ into long, unbranched fibrils is a hallmark of the disease, as is the loss of neurons due to ...

Results of a new study challenge the findings of previous work on the initial aggregates formed by amyloid beta ... the so-called beta-sheet. It should be noted that up to now drug design has ...

Amyloid beta, for example, may be less toxic when organized into fibrils ... Chemists will gather at the first rippled sheet symposium on March 17. The conversation has come a long way in just a few ...

Sun and colleagues were able to make measurements of amyloid fibril beta-sheet assemblies, the underlying girders of the protein conglomeration, while they were changing. Previous high-resolution ...

Contiguous β-sheet polypeptide chains ... important unsolved problems in amyloid research. Specific proteins aggregate predominantly in defined target organs: beta 2-microglobulin in joints ...

Recent approvals by the Food and Drug Administration have focused on medications that shrink the sticky brain deposits of a protein called amyloid beta. The errant growth of this protein is ...

Keep reading to learn about the pros and cons of anti-amyloid therapies in treating Alzheimer’s disease. Part of the disease process of Alzheimer’s is the buildup of beta-amyloid protein in ...

For three decades University College London neurogeneticist John Hardy and like-minded scholars have been so dominant in promoting the theory that amyloid-beta plaques are the root cause of ...

The new measures align with recently published proper use recommendations for Leqembi, Eisai’s and Biogen’s FDA-approved anti-amyloid beta therapy. Both Leqembi and Eli Lilly’s Kisunla ...