the method appears to be work independent of a protein’s amino acid sequence. “In principle, this is a more general way to put ketones into the backbone,” Van der Donk says.

Sialic acids are a family of alpha-keto acid sugars with a nine-carbon backbone, functioning as terminal ... The metabolism of Neu5Ac produces various amino sugar derivatives such as N ...

Starting with LCB1, a mutation-sensitive RBD-binding molecule, they developed a 39-amino acid peptide ... engineered to recognize the stable backbone of the RBD, which remains unchanged even ...