The most important name on the list for the Jaguars is starting wide receiver Dyami Brown, who left last week's game vs. the Houston Texans with a shoulder injury and did not return. After missing practice on Wednesday, Brown was limited on Thursday and Friday and seems like he has a solid chance of playing.

San Francisco head coach Kyle Shanahan said Purdy "looked good" in practice this week and got to do "a lot more" than he did last week, ramping up to the 49ers' Week 4 home matchup against the 2-1 Jaguars.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-19 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Records: Jaguars 2-1, 49ers 3-0. The Jaguars beat Houston 17-10. The 49ers beat Arizona 16-15. The Jaguars are listed by BetMGM at minus-3 and +145 on the moneyline. The 49ers are -175. The over-under is 46.5 points.

When Trent Williams struggled in the San Francisco 49ers' first game of the season, alarm bells went off across social media. But the 37-year-old tackle has regained his past form.

Arik Armstead makes his return to Levi's Stadium for the first time since the San Francisco 49ers cut him in the 2024 offseason. The 49ers released him after he

SANTA CLARA — In the days leading up to the 2025 season, Charles Woodson of Fox Sports sat down with Travis Hunter, a pair of Heisman Trophy winners renowned for excelling on offense and defense.

While Aiyuk's return is not in the offing, Lynch had better news regarding quarterback Brock Purdy and tight end George Kittle.