To report our methods for expression and purification of α7 nicotinic acetylcholine receptor (α7-nAChR), a ligand-gated pentameric ion channel and an important drug target. α7-nAChRs of 10 ...

today announced an update on the company’s α7 Nicotinic Acetylcholine Receptor (nAChR) Positive Allosteric Modulator (PAM) collaboration with MSD (known as Merck & Co., Inc., Rahway NJ ...

Activation of the α7 nicotinic acetylcholine receptor may be therapeutically useful against acute lung injury by suppressing expression of pro-inflammatory genes.

Written up as a novel, the relationship between Aβ and the α7 nicotinic acetylcholine receptor (α7 nAChR) has the makings of a bestseller—promise, peril, and mystery. Though earlier pages have ...

After striking out for years to characterize the structure of a key nicotinic acetylcholine receptor called α7, Noviello and Hibbs got a major boost in 2016 after UTSW purchased equipment for ...

Initiation by Merck of a Phase 2 trial in Alzheimer’s disease with partnered α7 nicotinic acetylcholine receptor PAM MK-1167 highlights company’s pipeline diversification beyond BNC210 US $ ...

Activation of nicotinic receptors by acetylcholine in the frontal ... of information ("learning") was dependent on the α7 nicotinic receptor, and subsequent memory retrieval ("remembering ...

Days before the masses swarmed to Chicago for the Society for Neuroscience annual meeting, a more intimate assembly of 287 exchanged the latest buzz on nicotinic acetylcholine receptors ... α4β2 and ...

More information: Spyridon Papapetropoulos et al, BNC210, an α7 Nicotinic Receptor Modulator, in Post-Traumatic Stress Disorder, NEJM Evidence (2024). DOI: 10.1056/EVIDoa2400380 Journal ...