The first-ever image of PINK1 proteins represents a groundbreaking moment in Parkinson’s disease research. This pivotal ...

In particular, PINK1 has been linked to young-onset Parkinson’s Disease, which affects people under the age of 50. Despite the known link, researchers have previously been unable to visualise ...

However, in many Parkinson’s disease cases, mutations in the PINK1 gene prevent this crucial protein from performing its protective duties. The result is a toxic build-up of damaged mitochondria ...

This article reviews the PINK1 protein product, which has been implicated in several functions, mostly aimed at protecting neuronal cells against different types of stress.

The PINK1 ubiquitin signal is unique to damaged mitochondria, and when PINK1 is mutated in patients, broken mitochondria accumulate in cells. Although PINK1 has been linked to Parkinson’s, and in ...

PINK1, a ubiquitin kinase that causes early onset Parkinson’s disease when mutated, functions as an early warning system for faltering mitochondria (Valente et al., 2004). Under normal conditions, ...

Mutants in Pink1, or PTEN-induced kinase 1, cause recessive Parkinson disease (PD), but exactly how is not clear. In yesterday’s online EMBO Molecular Medicine, the newest journal published by the ...

Researchers have discovered more about PINK1, a protein that’s directly tied to Parkinson’s disease. A team from Walter and Eliza Hall Institute in Australia has shown how the protein attaches ...

Since PINK1 is needed to start building these ubiquitin chains, Dr. Youle's work suggests a new avenue for creating drugs that treat disease by boosting the disposal of damaged mitochondria.

PINK1 deficiency is associated with an intramitochondrial calcium increase, which causes inhibition of the respiratory chain and ATP synthesis disruption, with a decrease in mΔΨ and accumulation ...