Despite dealing with a slew of injuries, the 49ers are 3-0 to start the 2025 NFL season. They have been without starting QB Brock Purdy for the last two games. Jauan Jennings missed their game in Week 3, and Brandon Aiyuk has yet to take a snap as he continues to recover from an ACL tear. However, they took a massive injury hit this week.

Brock Purdy’s toe has improved after 2 1/2 weeks on the mend but he claimed “we’ll see” whether his two-game hiatus ends Sunday when the 49ers host Jacksonville.

NFL Week 4 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and San Francisco 49ers.

We have a big one in Santa Clara this weekend, and it's time to make some Jaguars-49ers bold predictions for the game. The Jacksonville Jaguars will travel to Santa Clara, California, to face the San Francisco 49ers this weekend at Levi Stadium.

San Francisco star defensive end Nick Bosa tore the ACL in his right knee and will miss the rest of the season.

The NFC West had its first week of multiple losses. The San Francisco 49ers took control of the division as the only undefeated team, while the LA Rams and Arizona Cardinals suffered their first defeats of the season. No one in the division has more than one loss, but two are 0-1 in the division.

Shilo Sanders is hoping to keep his NFL dreams alive after being released by the Tampa Bay Buccaneers, and he got one step closer to doing so on Tuesday.

The San Francisco 49ers are on the verge of going 4-0 with a win this weekend at home against the Jacksonville Jaguars. Once again, it appears the 49ers will be a bit shorthanded on the injury front, and Jacksonville is going to bring a few challenges of its own. It will force the following players to perform their best.