The Buffalo Bills were 11.5-point favorites in Week 3, per FanDuel, and are once again expected to run away with a victory in Week 4.

Find single game tickets to the Buffalo Bills vs. New Orleans Saints NFL Week 4 matchup on Sunday, September 28, 2025 at Highmark Stadium.

The Buffalo Bills and New Orleans Saints are set for action in Week 4 of the NFL season. Buffalo is hoping to keep its undefeated season alive, while the Saints are trying to find a way to squeak out a victory.

Here are your Five Things to Know about the New Orleans Saints for Thursday, September 25:

The Bills only listed four players on Wednesday’s injury report. Defensive end AJ Espenesa was limited with a pectoral injury, while defensive tackle Ed Oliver, linebacker Matt Milano, and offensive lineman Spencer Brown didn’t participate.

Ed Oliver was the best player on the Bills' defense the Week 1 rally over the Baltimore Ravens .. The seventh-yar defensive tackle had six tackles, three tackles for loss, a sack and a comeback-igniting forced fumble on Derrick Henry.

In one of the most unwatchable games in New Orleans Saints history, the Black & Gold lost to the Seattle Seahawks 44-13, and the game never felt that close. Head Coach Kellen Moore's team was down 21-0 midway through the 1st quarter and trailed 38-6 at halftime.