Preston is a village in Hickory County, Missouri, United States. The population was 157 at the 2020 census. Preston was platted in 1857. Some say the community was named after Samuel Preston, a pioneer citizen, while others believe the name is a transfer from Preston, Pennsylvania. A post office called Preston has been in operation sinc…Preston is a village in Hickory County, Missouri, United States. The population was 157 at the 2020 census. Preston was platted in 1857. Some say the community was named after Samuel Preston, a pioneer citizen, while others believe the name is a transfer from Preston, Pennsylvania. A post office called Preston has been in operation since 1881.