The Kruzgamepa River is a 55-mile tributary of the Kuzitrin River on the Seward Peninsula in the U.S. state of Alaska. The river begins at Salmon Lake, elevation 447 feet, and descends to 20 feet above sea level at its mouth. In turn, the Kuzitrin River empties into the Imuruk Basin. The basin drains via the bay of Port Clarence to the Bering Sea.