Colón is a municipality and city in the Matanzas Province of Cuba. The municipality has an area of 547 km² and a population of about 68,021…Colón is a municipality and city in the Matanzas Province of Cuba. The municipality has an area of 547 km² and a population of about 68,021. The city proper, with a population of about 44,000, is the third-largest of its province.