Clarksville City is a city in Gregg and Upshur counties in the U.S. state of Texas. The population was 780 at the 2020 census. The first settlers arrived in the area before 1845. There was a stagecoach stop at the home of William W. Walters, which was later owned and operated by Warren P. Victory. Though first known as "Gilead", the post office was named "Point Pleasant" in 1852. It closed in 1867. The community withered when the railroad bypassed it in 1873 and Gladewater was established. With the advent of the East Texas Oil Field in 1930, so many homes, businesses, and oil-company camps and offices sprang up along the highway that it was called the Main Street of Texas, and street numbers were designated from Longview to Gladewater. The area around George W. Clark's home on the site of the old stagecoach stop became known as "Clarksville".