Appleton City is a city in St. Clair County, Missouri, United States. The population was 1,032 as of the 2020 census. It is the most populous city in St. Clair County. Appleton City was originally called Arlington, and under the latter name was platted in 1870. The present name is after D.S. Appleton of the D. Appleton & Company, who contributed a $500 library to the city.
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